Palabras clave: sepsis, insuficiencia orgánica múltiple, disfunción mitocondrial
ABSTRACT Sepsis is still the leading cause of death in intensive care units. New therapeutic approach based on goals achieved to reduce the mortality rate, however continues to be high. During the evolution of the septic process, the systemic inflammatory response and metabolic response to trauma form the two main responses of compensatory type with which the organism is faced with sepsis. The different phases of the metabolic response to trauma denote different stages of organic adaptation, which often first evolves to a phase of multiple organ dysfunction and then a multiple organic failure. Basal energy expenditure in patients with sepsis is greatly diminished at the stage corresponding to multiple organ dysfunction. At this stage, the functional alterations that are observed are secondary to disoxia and decrease in the production of energy at the mitochondrial level. This phase of dysfunction is thought to be an adaptive phase of the body with the purpose of preserving the organic cell structure. In this article, we reviewed the mitochondrial alterations that are observed during the phase of multiple organ dysfunctions, its relationship with the therapeutic approach and the importance in mortality of these patients. Key words: sepsis, multiple organ failure, mitochondrial dysfunctions.
Keywords: sepsis, multiple organ failure, mitochondrial dysfunctions